The participants of this stage included the winners of the previous round and the top four teams in the national rankings: Vorskla, Kolos, Kryvbas, and Metalist 1925.

Metalist 1925 and Vorskla secured their places in the semifinals. Two additional quarterfinal matches have been postponed to the spring part of the season due to the significant number of players participating in the national teams of Ukraine.

2024/2025 Women's Ukrainian Cup. Quarterfinals

November 14, 2024

Obolon (Kyiv) — Metalist 1925 (Kharkiv) — 0:4 (0:1)

Goals: Khymych (5), Shabalina (47), Basanska (62), Olkhova (88, penalty).

November 16, 2024

Polissya (Zhytomyr) — Vorskla (Poltava) — 0:5 (0:3)

Goals: Podolska (11), Korsun (17), Kravchuk (39), Taleb (79), Osipyan (89).

Kolos (Kovalivka) — Kryvbas (Kryvyi Rih) — postponed

Ladomyr (Volodymyr) — SeaSters (Odesa) — postponed